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Stereospecific Total Synthesis of the Antiviral Agent Hamigeran B—Use of Large Silyl Groups to Enforce Facial Selectivity and to Suppress Hydrogenolysis

✍ Scribed by Derrick L. J. Clive; Jian Wang

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
133 KB
Volume
42
Category
Article
ISSN
0044-8249

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Stereospecific Total Synthesis of the An
Stereospecific Total Synthesis of the Antiviral Agent Hamigeran B—Use of Large Silyl Groups to Enforce Facial Selectivity and to Suppress Hydrogenolysis
✍ Derrick L. J. Clive; Jian Wang 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 132 KB

We report the stereospecific synthesis of hamigeran B (1, Scheme 1), which is an important member of a group of related compounds isolated [1] from a marine sponge. Hamigeran B has been found to have strong in vitro activity against polio and herpes viruses but little cytotoxicity. [1] The compound