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Synthesis of halogenoindirubins

✍ Scribed by Yasuhiro Tanoue; Yousuke Ikoma; Norihisa Kai; Takeshi Nagai

Publisher
Journal of Heterocyclic Chemistry
Year
2009
Tongue
English
Weight
73 KB
Volume
46
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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The synthesis of halogenoindirubins was attempted. The reaction of 3‐acetoxy‐6‐bromoindole (5) with 6‐bromoisation (10) in methanol with Na~2~CO~3~ produced 6‐bromo‐6′‐fluoroindirubin (11) in 80% yield. Its structure determination was mainly undertaken using ^1^H NMR spectroscopy. A similar reaction gave 6′‐bromoindirubin (12) and 6‐bromoindirubin (3) in moderate yields. J. Heterocyclic Chem., (2009).

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