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Synthesis of Graft Bacterial Polyesters for Nanoparticles Preparation

✍ Scribed by Estelle Renard; Céline Ternat; Valérie Langlois; Philippe Guerin

Book ID
102467873
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
95 KB
Volume
3
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

Graft copolymers of bacterial polyesters were prepared by direct condensation of poly(3‐hydroxyoctanoate‐co‐9‐carboxy‐3‐hydroxydecanoate) (PHOD) and poly(ethylene glycol) (PEG) or poly(lactic acid) (PLA). Nanoparticles from PHO, PHOD, PHOD‐g‐PEG, and PHOD‐g‐PLA were obtained by solvent displacement without stabilizer, and their stability in different aqueous media with different salt concentrations were studied. The results showed that the presence of hydrophilic PEG on the particle surface prevents the aggregation promotion by salts in aqueous solution. PHOD‐g‐PEG appears to be a promising candidate for site‐specific drug delivery systems.

^1^H NMR spectrum of PHOD‐g‐PLA in CDCl~3~.

magnified image^1^H NMR spectrum of PHOD‐g‐PLA in CDCl~3~.

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