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Synthesis of (+)-Goniothalamin and Its Enantiomer by Combination of Lipase-Catalyzed Resolution and Alkene Metathesis.

โœ Scribed by Eirik Sundby; Lars Perk; Thorleif Anthonsen; Arne Joergen Aasen; Trond Vidar Hansen


Publisher
John Wiley and Sons
Year
2004
Weight
58 KB
Volume
35
Category
Article
ISSN
0931-7597

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An efficient and facile chemoenzymatic synthesis of duloxetine by lipase mediated resolution of 3-hydroxy-3-(2thienyl)propanenitrile has been achieved. This process also describes an enantioconvergent synthesis of duloxetine via a Mitsunobu reaction.