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Chemoenzymatic synthesis of duloxetine and its enantiomer: lipase-catalyzed resolution of 3-hydroxy-3-(2-thienyl) propanenitrile

✍ Scribed by Ahmed Kamal; G.B.Ramesh Khanna; R Ramu; T Krishnaji

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
157 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

An efficient and facile chemoenzymatic synthesis of duloxetine by lipase mediated resolution of 3-hydroxy-3-(2thienyl)propanenitrile has been achieved. This process also describes an enantioconvergent synthesis of duloxetine via a Mitsunobu reaction.

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