Synthesis of glucopyranoside-based ligands for d-myo-inositol 1,4,5-trisphosphate receptors
β Scribed by Andrew M Riley; David J Jenkins; Rachel D Marwood; Barry V.L Potter
- Book ID
- 108309360
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 500 KB
- Volume
- 337
- Category
- Article
- ISSN
- 0008-6215
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π SIMILAR VOLUMES
myo-Inositol 1,4,6-u-&phosphate, in optically inactive and active forms, was prepared in order to compare its biological activity with that of myo-inositol 1,3,4,6-tetrakisphosphate which releases Ca2+ from an intracellular store.
Enzyme-catalyzed esterification of racemic 2,3-O-cyclohexylidene-myo-inositol (DL-1) proceeded exclusively in 1,4-dioxane to give optically pure L-1-O-acetyl-2,3-O-cyclohexylidene-myo-inositol (L-2) and D-2,3-O-cyclohexylidene-myo-inositol (D-1). A new practical route has been developed for the synt