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A chemoenzymatic synthesis of d-myo-inositol 1,4,5-trisphosphate

✍ Scribed by Lei Ling; Shoichiro Ozaki

Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 816 KB
Volume: 256
Category: Article
ISSN: 0008-6215
DOI: 10.1016/0008-6215(94)84226-4

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✦ Synopsis

Enzyme-catalyzed esterification of racemic 2,3-O-cyclohexylidene-myo-inositol (DL-1) proceeded exclusively in 1,4-dioxane to give optically pure L-1-O-acetyl-2,3-O-cyclohexylidene-myo-inositol (L-2) and D-2,3-O-cyclohexylidene-myo-inositol (D-1). A new practical route has been developed for the synthesis of D-myo-inositol 1,4,5-trisphosphate starting from D-1 via selective acylation of the 6-hydroxyl group.

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