Synthesis and Biological Evaluation of N
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Lingjian Zhu; Pengfei Cheng; Ning Lei; Jianzhong Yao; Chunquan Sheng; Chunlin Zh
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Article
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2011
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John Wiley and Sons
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English
โ 334 KB
๐ 2 views
## Abstract Homocamptothecin (hCPT) is a camptothecin (CPT) homologue with the insertion of a methylene (๏ฃฟCH~2~๏ฃฟ) spacer between the alcohol moiety and carbonyl group of the classical sixโmembered ฮฑโhydroxylactone ring. This modification provides higher lactone stability and did not impair its acti