Synthesis of benzocyclic ketones via pal
Synthesis of benzocyclic ketones via palladium-catalyzed cyclization of ω-(2-iodoaryl)alkanenitriles
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Alexandre A. Pletnev; Richard C. Larock
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Article
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2002
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Elsevier Science
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French
⚖ 96 KB
An efficient procedure for the synthesis of 2,2-disubstituted benzocyclic ketones by intramolecular carbopalladation of nitriles has been developed. The cyclization of substituted 3-(2-iodoaryl)propanenitriles affords indanones in high yields. The reaction is compatible with a wide variety of functi