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Synthesis of Fused Cyclopentenones through Palladium-Catalyzed Cyclization of 2-Iodoaryl Allenols

✍ Scribed by Alcaide, Benito; Almendros, Pedro; Alonso, José M.; Fernández, Israel; Khodabakhshi, Saeed


Book ID
121659315
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
506 KB
Volume
356
Category
Article
ISSN
1615-4150

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An efficient procedure for the synthesis of 2,2-disubstituted benzocyclic ketones by intramolecular carbopalladation of nitriles has been developed. The cyclization of substituted 3-(2-iodoaryl)propanenitriles affords indanones in high yields. The reaction is compatible with a wide variety of functi