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Carbopalladation of Nitriles: Synthesis of Benzocyclic Ketones and Cyclopentenones via Pd-Catalyzed Cyclization of ω-(2-Iodoaryl)alkanenitriles and Related Compounds

✍ Scribed by Pletnev, Alexandre A.; Larock, Richard C.


Book ID
121461761
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
238 KB
Volume
67
Category
Article
ISSN
0022-3263

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Synthesis of benzocyclic ketones via pal
✍ Alexandre A. Pletnev; Richard C. Larock 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 96 KB

An efficient procedure for the synthesis of 2,2-disubstituted benzocyclic ketones by intramolecular carbopalladation of nitriles has been developed. The cyclization of substituted 3-(2-iodoaryl)propanenitriles affords indanones in high yields. The reaction is compatible with a wide variety of functi