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Synthesis of Functionalized Sulfonamides via 1,3-Dipolar Cycloaddition of Pentafluorophenyl Vinylsulfonate

✍ Scribed by Caddick, Stephen; Bush, Hannah D.


Book ID
115450604
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
95 KB
Volume
5
Category
Article
ISSN
1523-7060

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We have developed a practical synthetic route to constrained b-strand mimetic templates by regioselective 1,3-dipolar cycloaddition of azomethine imines with vinyl sulfone. A small library of b-strand mimetic templates was generated which include potent and selective inhibitors of serine proteases.