Synthesis of functionalized biaryl compounds via ring expansion of alkenylcyclobutenones

✍ Scribed by Toshiyuki Hamura; Masato Morita; Takashi Matsumoto; Keisuke Suzuki

• Book ID: 104252584
• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 165 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)02473-5

✦ Synopsis

Various functionalized biaryls are accessible via a simple two-step process. Treatment of alkenylcyclobutenones with aryllithium provides ring-opened trienes, which are smoothly cycloaromatized under thermal conditions.