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Synthesis of functionalized 3-pyridyl methyl ketones

✍ Scribed by S. W. Wright; D. L. Hageman; L. D. McClure

Publisher
Journal of Heterocyclic Chemistry
Year
1998
Tongue
English
Weight
400 KB
Volume
35
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

A synthesis of 3‐pyridyl methyl ketones is described that employs a palladium‐catalyzed olefination of 3‐bromopyridines with butyl vinyl ether followed by acid hydrolysis of the intermediate pyridyl vinyl ether in situ. This method has been applied to bromoquinoline substrates as well. The reaction is compatible with a variety of functional groups.

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