An efficient stereoselective synthesis of methyl (S)-3-amino-3-(3-pyridyl)propanoate
✍ Scribed by H Marlon Zhong; Judith H Cohen; Ahmed F Abdel-Magid; Birdella D Kenney; Cynthia A Maryanoff; Rekha D Shah; Frank J Villani Jr.; Fan Zhang; Xini Zhang
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 299 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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## Abstract A synthesis of 3‐pyridyl methyl ketones is described that employs a palladium‐catalyzed olefination of 3‐bromopyridines with butyl vinyl ether followed by acid hydrolysis of the intermediate pyridyl vinyl ether __in situ__. This method has been applied to bromoquinoline substrates as we
## Abstract A synthesis of 3‐pyridyl methyl ketones is described that employs a palladium‐catalyzed olefination of 3‐bromopyridines with butyl vinyl ether followed by acid hydrolysis of the intermediate pyridyl vinyl ether __in situ__. This method has been applied to bromoquinoline substrates as we
## Abstract 3′‐Amino‐3′‐deoxyguanosine was synthesized from guanosine in eight steps and 58% overall yield. The 2′,3′‐diol of 5′‐__O__‐[(__tert__‐butyl)diphenylsilyl]‐2‐__N__‐[(dimethylamino)methylidene]guanosine was reacted with __α__‐acetoxyisobutyryl bromide and treated with 0.5n NH~3~ in MeOH t