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Synthesis of functionalized 2,3-dihydroisoxazoles by domino reactions in water and unexpected ring-opening reactions of 2,3-dihydroisoxazoles

โœ Scribed by Li, Ping ;Teng, Bo-Tao ;Jin, Fa-Gen ;Li, Xin-Sheng ;Zhu, Wei-Dong ;Xie, Jian-Wu


Book ID
120284360
Publisher
Royal Society of Chemistry
Year
2012
Tongue
English
Weight
237 KB
Volume
10
Category
Article
ISSN
1477-0520

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## Abstract Ringโ€opening reactions of 3โ€arylaziridineโ€2โ€carboxylic esters with various nucleophiles are described. Racemic methyl 3โ€(4โ€methoxyphenyl)โ€, 3โ€phenylโ€ and 3โ€(4โ€nitrophenyl)aziridineโ€2โ€carboxylate (1a, 1b and 1c, respectively) were selected as substrates. In the absence of acid, no ring o