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Synthesis of functionalised cephalosporins : Diphenylmethyl(1S,6R,7S)-3-bromomethyl-7-formamido-7-methoxyceph-3-em-4-carboxylate-1-oxide: a useful intermediate in the preparation of 7α-methoxycephalosporins

✍ Scribed by K. Biggadike; D.C. Humber; B. Laundon; A.G. Long; M.V.J. Ramsay


Book ID
108374426
Publisher
Elsevier Science
Year
1985
Tongue
French
Weight
742 KB
Volume
41
Category
Article
ISSN
0040-4020

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p-Nitrobenzyl (61L7S)-3-hydroxy-8-oxo-7-phenoxyacetamido-l-azabicyclo [4.2.0]octa-2-ene-2-carboxyate (6) was synthesized utilizing rhodium(II)-or acid-catalyzed cyclization of iodonium ylide (5). The iodonium ylide (5) was easily prepared from the corresponding 13-keto ester (4) and [(diacetoxy)iodo