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Use of an iodonium ylide in the synthesis of p-nitrobenzyl (6R, 7S) 3-hydroxy-8-oxo-7-phenoxyacetamino-1-azabicyclo[4.2.0]octa-2-ene-2-carboxylate

✍ Scribed by Radhe K. Vaid; Thomas E. Hopkins

Book ID
104257986
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
197 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

p-Nitrobenzyl (61L7S)-3-hydroxy-8-oxo-7-phenoxyacetamido-l-azabicyclo [4.2.0]octa-2-ene-2-carboxyate (6) was synthesized utilizing rhodium(II)-or acid-catalyzed cyclization of iodonium ylide (5). The iodonium ylide (5) was easily prepared from the corresponding 13-keto ester (4) and [(diacetoxy)iodo]benzene in good yield.

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