An efficient synthetic route to the glycobiosyl phosphatidylinositol is developed by use of a H-phosphonate intermediate.
Synthesis of fluorescent phosphatidylinositols using a novel inositol H-phosphonate
✍ Scribed by Lawrence W Leung; Catherine Vilchèze; Robert Bittman
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 226 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Highly electrophilic phosphorylating species, generated from an appropriately protected 5 '-U-(1 -H-phasphonate) nucleoside block 4 or 5 and pivaloyl chloride, followed by an oxidation step, has been used for the first time to introduce the branching phosphate vicinal to an internucleotidyl2 '
A fluorescent water-soluble substrate for phosphatidylinositol-specific phospholipase C was synthesized. The diacylglycerol moiety of the natural substrate, phosphatidylinositol, was replaced by the fluorescent moiety, 2-naphthol, resulting in the synthetic substrate, racemic 2-naphthyl myo-inositol