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A convenient synthesis of nucleoside 3′-H-phosphonate monoesters using triphosgene

✍ Scribed by Nandkumar N. Bhongle; Jin Yan Tang


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
186 KB
Volume
36
Category
Article
ISSN
0040-4039

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A new convenient route to phosphate monoesters from alcohols has been developed. H-Phosphonate monoesters, which are readily accessible by phosphonylation of the parent alcohols, were oxidized with t-BuOOH or N-sulfonyloxaziridines under anhydrous conditions via the corresponding bis(trimethylsilyl)