Development of a New Class of Inhibitors
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David A. Carcache; Simone R. Hörtner; Paul Seiler; François Diederich; Arnulf Do
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Article
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2003
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John Wiley and Sons
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German
⚖ 289 KB
## Abstract Plasmepsin II (PMII), a malarial aspartic protease involved in the catabolism of hemoglobin in parasites of the genus __Plasmodium__, and renin, a human aspartic protease, share 35% sequence identity in their mature chains. Structures of 4‐arylpiperidine inhibitors complexed to human re