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Synthesis of exo-3-Amino-7-azabicyclo[2.2.1]heptanes as a Class of Malarial Aspartic Protease Inhibitors: Exploration of Two Binding Pockets

✍ Scribed by Martina Zürcher; Fraser Hof; Luzi Barandun; Andri Schütz; W. Bernd Schweizer; Solange Meyer; Daniel Bur; François Diederich


Book ID
102828503
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
813 KB
Volume
2009
Category
Article
ISSN
1434-193X

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## Abstract Plasmepsin II (PMII), a malarial aspartic protease involved in the catabolism of hemoglobin in parasites of the genus __Plasmodium__, and renin, a human aspartic protease, share 35% sequence identity in their mature chains. Structures of 4‐arylpiperidine inhibitors complexed to human re