Design and synthesis of 6-substituted amino-4-oxa-1-azabicyclo[3,2,0]heptan-7-one derivatives as cysteine proteases inhibitors
✍ Scribed by Nian E Zhou; Deqi Guo; Jadwiga Kaleta; Enrico Purisima; Robert Menard; Ronald G Micetich; Rajeshwar Singh
- Book ID
- 108477337
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 105 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0960-894X
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📜 SIMILAR VOLUMES
Four novel stereoisomers of 7-(1-phenylethyl)-2-oxa-7-azabicyclo[3.2.0]heptan-6-one were prepared under high pressure from [2 ] 2] cycloaddition of the pure enantiomers of 1-phenylethyl isocyanate and 2,3dihydrofuran. Their conformational preferences in solution and the absolute conÐgurations of the
## Abstract Ethyl 4‐oxoalkanoates 1 react at ambient temperature in dry methanol in the presence of molecular sieve 3 Å in almost quantitative yield with 3‐aminopropanol and 2‐aminoethanol to form the bicyclic lactams __rac__‐2 and __rac__‐3, respectively. Surprisingly, the (±)‐5‐alkyl‐4‐oxa‐1‐azab