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Synthesis of Epibatidine Analogues Having a 2-Substituted 2-Azabicyclo[2.2.2]octane Skeleton

✍ Scribed by Wauters, Iris; De Blieck, Ann; Muylaert, Koen; Heugebaert, Thomas S. A.; Stevens, Christian V.


Book ID
121785157
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
569 KB
Volume
2014
Category
Article
ISSN
1434-193X

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A synthetic route to the epibatidine analogue endo-5-(6-chloro-3-pyridyl)-2-azabicyclo[2.2.1]heptane and the corresponding endo-6-isomer is described, starting from a readily-available 2-azabicyclo[2.2.1]hept-5-ene derivative. Both the exo-5-and exo-6-compounds are also shown to be accessible from t