The synthesis of ent-19-nortestosterone from natural 19-nortestosterone is described. The synthetic sequence takes advantage of the 'near symmetry' properties of the steroid; removal/introduction of a methyl group and conversion of the A-into the D-ring and vice versa eventually results in overall i
Synthesis of ent -Kaurene From a Naturally Occurring Precursor
β Scribed by Hogg, RW; Knox, JR
- Book ID
- 118264484
- Publisher
- Commonwealth Scientific and Industrial Research Organisation Publishing
- Year
- 1987
- Tongue
- English
- Weight
- 289 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0004-9425
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Paclitaxel, an antitumor drug effective on ovarian and breast carcinomas, is currently being produced both by direct isolation from the bark of __Taxus brevifolia__ and by semiβsynthesis from a natural precursor, 10βdeacetyl baccatin III. Although other potential precursors such as 10βd
9-Hydroxymegastigma-3,5-dien-7-yne 8a was synthesised and shown to be identical to an intermediate found in the acid-catalysed conversion of 3,5,9-trihydroxymegastigma-6,7-diene 4 to b-damascenone 1, 3-hydroxydamascone 5 and megastigma-5-en-7-yne-3,9-diol 6. When subjected to acid hydrolysis, 8a pro