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Synthesis of ent-19-nortestosterone from its naturally occurring antipode

✍ Scribed by N.Miranda Teerhuis; Inès A.M Huisman; Marinus B Groen

Book ID
104230368
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
91 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

The synthesis of ent-19-nortestosterone from natural 19-nortestosterone is described. The synthetic sequence takes advantage of the 'near symmetry' properties of the steroid; removal/introduction of a methyl group and conversion of the A-into the D-ring and vice versa eventually results in overall inversion of the stereochemistry.

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