Concise Synthesis of the Unnatural Sphin
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Archana R. Parameswar; Jacqueline A. Hawkins; Laurel K. Mydock; Mark S. Sands; A
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Article
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2010
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John Wiley and Sons
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English
β 171 KB
## Abstract The accumulation of psychosine (galactosyl sphingosine) has been associated with the pathogenesis of Krabbe disease; however, the exact mechanism of its cytotoxicity remains unclear. Herein, we describe the synthesis of the unnatural enantiomer of erythroβsphingosine, psychosine, and re