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Synthesis of Enantiopure 3-Substituted Morpholines

✍ Scribed by Bornholdt, Jan; Felding, Jakob; Kristensen, Jesper Langgaard

Book ID
111864258
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
715 KB
Volume
75
Category
Article
ISSN
0022-3263

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✍ Jean Nonnenmacher; Fabienne Grellepois; Charles Portella πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 191 KB πŸ‘ 1 views

## Abstract The synthesis of morpholines and oxazepanes derivatives containing a trifluoromethyl group on a quaternary carbon has been achieved from a common enantiopure __O__‐allyl amino ether precursor. Classic 6‐__exo__ iodoamination provided the iodomorpholines, versatile synthetic intermediate