## Abstract Enantiomerically pure ^13^C‐ and ^1^H‐labeled (__R__)‐mevalonolactones are prepared from (__S__)‐malic and/or (__S__)‐lactic acid by Seebachs methodology of self‐reproduction of chirality. The two reaction pathways are complementary in the possibilities of multiple isotopic labeling. Th
Synthesis of enantiomerically pure (S)-(+)-3-hydroxytetrahydrofuran, and its (R)-enantiomer, from malic or tartaric acid
✍ Scribed by Tandon, Vishnu K.; Van Leusen, Albert M.; Wynberg, Hans
- Book ID
- 120007527
- Publisher
- American Chemical Society
- Year
- 1983
- Tongue
- English
- Weight
- 441 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0022-3263
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📜 SIMILAR VOLUMES
## Abstract Starting from __R__,__R__‐(+)‐tartaric acid, the synthesis of (2__S__,3__R__,4__R__6__E__)‐3‐hydroxy ‐4‐methyl‐2‐methylamino‐6‐octenoic acid in 24 steps is reported. This novel amino acid is found in the cyclic undecapeptide cyclosporin A, isolated from the fungal strain __Tolypocladium
Ac acetate; Bz benzoate; PG protecting group; Tris 2,4,6-triisopropylphenylsulfonyl; TES triethylsilyl; TBAF tetrabutylammonium fluoride. [9] A detailed analysis of the synthesis of the metathesis precursors will be reported elsewhere. [10] S. D. Edwards, T. Lewis, R. J. K. Taylor, Tetrahedron Let