Synthesis of enantiomerically pure constrained γ-hydroxy-α-amino acids by directed hydroxylation
✍ Scribed by Alberto Avenoza; Carlos Cativiela; Miguel París; Jesús M. Peregrina; Beatriz Saenz-Torre
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 512 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0957-4166
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The amide group of y&unsaturated amino acids can be used for the preparation of yhydroxya-amino acids. Product 2, which is easily obtained by hydrolysis of the spiro-oxazoloneadduct formed in the Diels-Alder reaction between (Z)-2-phenyl-4-benzylidene-5(4H)-oxaxolone 1 and 1,3butadiene. was converte
Optically active cis-, 8a and 8b, and trans-l-aminomethyl-2-phenylcyclohexane-1carboxylic acids, 9a and 9b, were obtained starting from 1,3-butadiene using Diels-Alder cycloadditions with chiral (E)-2-cyanocinnamates as key steps and following a protocol of stereocontrolled reactions. Subsequent cyc