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Synthesis of enantiomerically pure (2R, 5S)- and (2R, 5R)-5-hydroxypipecolic acid from glycinate Schiff bases

✍ Scribed by Sylvie Hoarau; Jean Luc Fauchère; Louis Pappalardo; Marie Louise Roumestant; Philippe Viallefont


Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
414 KB
Volume
7
Category
Article
ISSN
0957-4166

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Synthesis of enantiomerically pure (2R,
✍ M. Marzi; P. Minetti; D. Misiti 📂 Article 📅 1992 🏛 Elsevier Science 🌐 French ⚖ 515 KB

Pyrrolidines 1 and 2 are obtained from D-Mannitol, giving good total yields and in an enantiomerically pure form. Some commentS and studies regarding pyrrolidine ring closure (key step) are also qorted. Over the last few years, interest in pyrrolidine-type derivatives has grown considerably, from b