✦ LIBER ✦

Synthesis of (±)duryne

✍ Scribed by V.H. Deshpande; B.K. Upadhye; R.D. Wakharkar

Book ID: 104229784
Publisher: Elsevier Science
Year: 1989
Tongue: French
Weight: 149 KB
Volume: 30
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)99632-1

No coin nor oath required. For personal study only.

✦ Synopsis

Synthesis of cytotoxic metabolite, duryne (l), involving symmetrical synthetic strategy is described. There has been considerable growth in the newly discovered biologically active marine natural products in the last decade'. Recently, Wright et al.' reported the isolation of duryne (I) from marine sponge Cribrachalina dura which inhibits the growth of a number of in vitro tumour cell lines. The structure of duryne was established on the basis of spectroscopic analysis as a symmetrical CjO dial, consisting of two terminal acetylenic groups,two asymmetric centres and three olefinic bands. Although the geometry of two double bonds at C4 and C4', is E, the geometry

📜 SIMILAR VOLUMES

An organocatalytic enantioselective synt

An organocatalytic enantioselective synthesis of (+)-duryne

✍ Gullapalli Kumaraswamy; Kadivendi Sadaiah; Nimmakayala Raghu 📂 Article 📅 2012 🏛 Elsevier Science 🌐 English ⚖ 816 KB

Duryne, a new cytotoxic agent from the m

Duryne, a new cytotoxic agent from the marine sponge Cribrochalina dura

✍ Amy E Wright; Oliver J McConnell; Shigeo Kohmoto; May S Lui; Winnie Thompson; Ke 📂 Article 📅 1987 🏛 Elsevier Science 🌐 French ⚖ 150 KB

Duryne, 1, a cytotoxic metabolite which inhibits the growth of both mouse and human tumor cell lines in vitro has been isolated from the marine sponge Cribrochalina dura. Its -structure has been assigned by spectral methods.

(−) - Duryne and Its Homologues, Cytotox

(−) - Duryne and Its Homologues, Cytotoxic Acetylenes from a Marine Sponge Petrosia sp.

✍ Hitora, Yuki; Takada, Kentaro; Okada, Shigeru; Ise, Yuji; Matsunaga, Shigeki 📂 Article 📅 2011 🏛 American Chemical Society 🌐 English ⚖ 853 KB

An Efficient Derivation of the Versatile

An Efficient Derivation of the Versatile Chiron Antipode 1- tert -Butyldimethylsilylpenta-1,4-diyn-3-ol: Application to the Synthesis of (15 E , R , R )-Duryne

✍ Sharma, A.; Chattopadhyay, S. 📂 Article 📅 1998 🏛 American Chemical Society 🌐 English ⚖ 53 KB

ChemInform Abstract: An Efficient Deriva

ChemInform Abstract: An Efficient Derivation of the Versatile Chiron Antipode 1-tert-Butyldimethylsilylpenta-1,4-diyn-3-ol: Application to the Synthesis of (15E,R,R)-Duryne.

✍ A. SHARMA; S. CHATTOPADHYAY 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 1 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Total Synthesis of (+)- and (−)-Duryne:

Total Synthesis of (+)- and (−)-Duryne: A Potent Anticancer Agent from the Marine Sponge Cribrochalina Dura. Establishment of the Central Double Bond Geometry and the Absolute Configuration of the Chiral Centers

✍ Gung, Benjamin W.; Omollo, Ann O. 📂 Article 📅 2008 🏛 American Chemical Society 🌐 English ⚖ 70 KB