𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of Doubly Cross-Linked Cyclic Hexapeptides

✍ Scribed by Patrik D. Bailey; Steven R. Carter; David G.W. Clarke; Gavin A. Crofts; Joanna H.M. Tyszka; Paul W. Smith; Peter Ward


Publisher
Elsevier Science
Year
1992
Tongue
French
Weight
298 KB
Volume
33
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis


Akfrucl.

Cyclic hexapzptides in which the adjacent Ne-nitrogens of cycle-(Lys-Lys-tily)2 arc cross-linked by pxylyl or (CH& units have been prepared. The key steps in the syntheses of these novel types of peptide wcrc the use


📜 SIMILAR VOLUMES


Solution-Phase Synthesis of Aib-Containi
✍ Tatjana Jeremic; Anthony Linden; Heinz Heimgartner 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 771 KB

## Abstract The 18‐membered Aib‐containing cyclohexapeptides, cyclo(‐Gly‐Aib‐Aib‐Gly‐Aib‐Phe‐) (**22**), cyclo(‐Gly‐Aib‐Phe(2Me)‐Gly‐Aib‐Aib‐) (**24a**), cyclo(‐Gly‐Phe(2Me)‐Aib‐Gly‐Aib‐Aib‐) (**24b**), and cyclo(‐Gly‐Phe(2Me)‐Aib‐Gly‐Aib‐Phe‐) (**25**), have efficiently been synthesized by solutio

Solid-phase synthesis of hydroxyproline-
✍ Andrea Basso; Beat Ernst 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 64 KB

Cyclic peptides are excellent tools to investigate the functional and spatial requirements for ligands to bind to a given target. In this paper we report the synthesis of a library of cyclic hexapeptides, designed to be Selectin antagonists. Based on molecular modelling calculations, these peptides

Synthesis of phenolically linked cyclic
✍ Michael J. Crimmin; Allan G. Brown 📂 Article 📅 1990 🏛 Elsevier Science 🌐 French ⚖ 212 KB

Cyclixation of a diary1 ether containing an or, m-amino acid residue leads to cyclic peptides which resemble the vancomycin binding pocket The glycopeptide antibiotics, exemplified by vancomycin, are believed to act by complexation with the car-boxy1 terminal of a pentapeptide unit which usually for