Synthesis of dolichols via asymmetric hydrogenation of plant polyprenols

✍ Scribed by Barbara Imperiali; Janec Warren Zimmerman

• Book ID: 104217938
• Publisher: Elsevier Science
• Year: 1988
• Tongue: French
• Weight: 158 KB
• Volume: 29
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)82862-2

✦ Synopsis

S)-Dolichols can be prepared from polyprenols extracted from Ginkgo biloba leaves by asymmetric hydrogenation. The dolichols are obtained in high yield and >95% optical purity.

The dihydropolyisoprenols which comprise the homologous family of (S)-dolichols are crucial metabolites in glycoprotein biosynthesis. The hydrophobic nature of the isoprenols