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Synthesis of DNA/RNA and Their Analogs via Phosphoramidite and H-Phosphonate Chemistries

✍ Scribed by Roy, Subhadeep; Caruthers, Marvin

Book ID
121464081
Publisher
Molecular Diversity Preservation International
Year
2013
Tongue
English
Weight
680 KB
Volume
18
Category
Article
ISSN
1420-3049

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✍ Jean-Charles Bologna; FranΓ§ois Morvan; Jean-Louis Imbach πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 232 KB πŸ‘ 1 views

The synthesis of mixed SATE-phosphotriester and phospho-linkages to yield thiono-or oxo-triester SATE and thiono-or oxo-diester linkages. This approach allows the synthesis of diester prooligonucleotides using both phosphoramidite and H-phosphonate chemistries is described. The key step is the any d