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Synthesis of dispacamide from the marine sponge agelas dispar

✍ Scribed by Thomas Lindel; Holger Hoffmann


Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
174 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis


The marine natural product dispacamide (1) has been synthesized for the first time starting from 2thiohydantoin (2). A facile one pot conversion of alkylideme thiohydantoins to the corresponding 2-iminoimidazoiones is described employing tert.-butylhydroperoxide (TBHP) in the presence of aqueous ammonia.


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