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Synthesis of disaccharide fragments of the AT-III binding domain of heparin and their sulfonatomethyl analogues

✍ Scribed by Mihály Herczeg; László Lázár; Attila Mándi; Anikó Borbás; István Komáromi; András Lipták; Sándor Antus


Book ID
113515303
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
942 KB
Volume
346
Category
Article
ISSN
0008-6215

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Heparin, highly sulfated glycosaminoglycan, binds to platelets. A key disaccharide unit in heparin was previously found to be responsible for the binding, and the frequency of the disaccharide unit was important for the binding potency. A newly developed method based on the reductive amination was e