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Synthesis and Anticoagulant Activity of Bioisosteric Sulfonic-Acid Analogues of the Antithrombin-Binding Pentasaccharide Domain of Heparin

✍ Scribed by Dr. Mihály Herczeg; Dr. László Lázár; Dr. Zsuzsanna Bereczky; Prof. Dr. Katalin E. Kövér; István Timári; Prof. Dr. János Kappelmayer; Prof. Dr. András Lipták; Prof. Dr. Sándor Antus; Dr. Anikó Borbás


Book ID
112020328
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
538 KB
Volume
18
Category
Article
ISSN
0947-6539

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The synthesis of tri-N-acetylated heparin pentasaccharide 2 is described. It was assembled from five suitably blocked monosaccharide units (S7). Glucuronic-acid building block 4 was prepared from glucose by direct Jones oxidation of the 6-0-trityl derivative 18. The resulting acid 16 was esterified