The 3-O-acyl derivatives of serine and threonine have been prepared by reacting oleoyl chloride and palmitoyl chloride with N-t-butoxycarbonyl (N-T-BOC) serine and N-t-BOC threonine. The t-BOC group was removed by treatment with 4 N HCI in dioxane. The products were identified by proton magnetic res
Synthesis of dinitrophenyl derivatives of 3-O-fatty acyl esters of serine and threonine
โ Scribed by Guido V. Marinetti; Michael Siani
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 249 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0009-3084
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โฆ Synopsis
The synthesis of 2,4-dinitrophenyl derivatives of the 3-O-oleoyl and 3-O-palmitoyl esters of serine and threonine are described. The derivatives were purified by preparative thin-layer chromatography (TLC) and characterized by 1H-nuclear magnetic resonance (NMR) spectroscopy. These derivatives may be useful for researchers interested in characterizing covalently bound fatty acids on serine and threonine hydroxyl groups of cellular proteins.
๐ SIMILAR VOLUMES
The galactosyl derivatives Galp-Ser(N-Boc) and Galp-Thr(N-Boc) of N-Boc-protected serine and threonine were prepared with galactose or lactose as the glycosyl donor employing 8galactosidase as the catalyst. Similarly, the mannosyl derivatives Mana-Ser(N-Boc) and Mana-Thr(N-Boc) were prepared with ma
Cyclization of serine and threonine derivatives with Burgess reagent provides a one-step, stereospecific access to 45dihydrooxazoles. Noteworthy features of this new methodology include mild experimental conditions, and the absence of p-lactam. aziridine. or dehydroamino acid side products.