Synthesis of dimeric lactose and dimeric (sialyl) LewisX glycolipids
β Scribed by Christian Gege; Richard R Schmidt
- Book ID
- 108309357
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 181 KB
- Volume
- 337
- Category
- Article
- ISSN
- 0008-6215
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π SIMILAR VOLUMES
E-selectin (endotherial-leukocyte adhesion molecule-l), P-selectin (GMP-140) and L-selectin (leukocyte adhesion molecule-l) belong to a family of adhesion molecules that mediate the binding of leucocytes to endothelial cells and platelets, as well as to lymphocyte-homing receptors. The ligand recogn
Readily available fucosyl ct(l-3)azidoglucose disaccharide 6 is transformed with galactosyl donors 7 and 8 into Lewis X trisacchadde building blocks 9 and 12, respectively, in high yield. Their suitability for the construction of the lactoneo-series glycosphingolipids is demonstrated. For instance,