Chemoenzymatic Synthesis of Sialyl Lewisx Glycopeptides
✍ Scribed by Gabi Baisch; Dr. Reinhold Öhrlein
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 480 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The decasaccharide sialyl-trimeric-Lewis x is a component of glycoproteins and glycolipids that serve as E-and P-selectin ligands. The synthesis of this target structure was accomplished by utilizing a combination of chemical and enzymatic methods. Highlights of the chemical synthesis include minima
Sialyl-T-glycopeptides were synthesized by solid-phase techniques, using a PEGA resin as the solid support. An appropriately protected building block containing alpha-Neu5Ac-(2 --> 3)-beta-Gal-(1 --> 3)-alpha-GalN3-(1-->) attached to Fmoc-Thr/Ser-OPfp was employed in a solid phase glycopeptide assem