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Synthesis of di-, tetra, and hexadeuterated 11-octadecenoates

✍ Scribed by W. J. Dejarlais; E. A. Emken

Book ID
102371695
Publisher
John Wiley and Sons
Year
1978
Tongue
French
Weight
353 KB
Volume
15
Category
Article
ISSN
0022-2135

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✦ Synopsis

Methyl esters of 11-octadecenoic-15 ,l6-d2, -15,lS ,16,16-d4, and -1O,lO, 15,15,16,16-d prepared by Wittig synthesis from intediates derived fran ll-bmmomdecmoic acid and 7-chloro-3-heptyne. Ihe dideuterated acid was prepared by partial hydrogenation of the heptyne f o l l d by saturation with deuteriun to l-chloroheptane-4,5-d2 for Wittig synthesis. Saturation of the heptyne w i t h deuterim provided the Wittig intermediate for tetradeuterated acids. The hexadeuterated acids were prepared frcm tetradeuterated alkyl halide and 10-formyldecanoate-10,10-d2. a ~l d s were

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