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Synthesis of deuterium-labelled peptido-aminobenzophenone [4-chloro-2-(2′-chlorobenzoyl)-N-(glycylglycyl)-N-methyl-anilide] and its metabolites

✍ Scribed by Shin'Ichirō Hashimoto; Shirō Takahashi

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
529 KB
Volume
19
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Deuterium‐labelled peptido‐aminobenzophenone [4‐chloro‐2‐(2′‐chlorobenzoyl)‐N‐(glycylglycl)‐N‐methylanilide, 1] and its benzodiazepine‐metabolites were prepared for use as internal standards in the quantification of the peptido‐aminobenzophenone, chlorodiazepam, lormetazepam, chlorodesmethyldiazepam, and lorazepam at low levels in human plasma by selected ion monitoring.

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