Synthesis of deuterium-labeled 3-O-methyldopa and 4-O-methyldopa

✍ Scribed by Aruna Perera; Keith Hyland; Hoa K. Nguyen; Robert R. Kane

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: French
• Weight: 77 KB
• Volume: 46
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.677

✦ Synopsis

Concise methods for the synthesis of 4-hydroxy-3-

-methydopa is a valuable internal standard for the tandem MS quantification of 3-O-methyldopa, a metabolite of value in the diagnosis of aromatic l-amino acid decarboxylase (AADC) deficiency.