## Abstract The synthesis of tracer labelled [11,12‐^3^H]‐β‐carotene is described. The procedure uses Wittig condensation of tracer labelled ^3^H‐retinal (retinal spiked with [11,12‐^3^H]‐retinal) with retinyl triphenylphosphonium bromide. The preparation of tracer labelled[^3^H]‐β‐carotene is suit
Synthesis of deuterated β-carotene
✍ Scribed by H. Robert Bergen III; James A. Olson
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- French
- Weight
- 202 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
The synthesis of 10,lO' 19,19 , 19,19' , 19' 19'-2H8p-carotene is described. The double condensation (C15+C o+C15=C40) of the Wittig salt of 9 , 9 , 9 , 10-2H4-pionyliaene ethanol with the symmetrical Cl0 dial 2,7- dimethyl-2 , 4 , 6-octatrienedial led directly to 2H -pcarotene. The symmetrical labelling pattern of this deuterated p-carotene will function as a tracer for the study of ,+carotene metabolism in humans.
📜 SIMILAR VOLUMES
In response to a need for relative large amounts of highly labeled 14C p carotene, a search was made for a biological system which would supply an adequate amount of carotene with sufficient label. Methods previously described did not appear to be adequate appear to devote a greater part of their me
## Abstract For many years it was accepted that 6 mg of β‐carotene were required to produce 1 mg of vitamin A in the form of retinol. The equivalence was based on the assumptions that two‐thirds of dietary β‐carotene are not absorbed, while in the metabolism of the remaining third 1 mol of β‐carote