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Synthesis of dehydrophenylalanine derivatives by palladium catalyzed arylation of 2-acetamidoacrylic acid

✍ Scribed by M. Cutolo; V. Fiandanese; F. Naso; O. Sciacovelli


Publisher
Elsevier Science
Year
1983
Tongue
French
Weight
277 KB
Volume
24
Category
Article
ISSN
0040-4039

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The reactions of Grignard reagents with methyl 2-acetamidoacrylate in the presente of CuI give fair to good yields of cr-amino esters; the corresponding a-deutero-or a-methyl-derivatives are obtained upon quenching with D+ or CH31, respectively.