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Synthesis of (+)-Decarestrictine L.

โœ Scribed by Julie M. Lukesh; William A. Donaldson


Book ID
101941034
Publisher
John Wiley and Sons
Year
2003
Weight
61 KB
Volume
34
Category
Article
ISSN
0931-7597

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Synthesis of (+)-decarestrictine L
โœ Julie M. Lukesh; William A. Donaldson ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 251 KB

A synthesis of (+)-decarestrictine L 1, a cholesterol biosynthesis inhibitory metabolite isolated from Penicillium simplicissimum, is described. Beginning from tri-O-acetyl-D-glucal, alkylation with trimethylaluminum introduced the axial methyl group at C-2 in a stereoselective fashion. Chain extens