Synthesis of (+)-decarestrictine L
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Julie M. Lukesh; William A. Donaldson
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Article
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2003
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Elsevier Science
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English
⚖ 251 KB
A synthesis of (+)-decarestrictine L 1, a cholesterol biosynthesis inhibitory metabolite isolated from Penicillium simplicissimum, is described. Beginning from tri-O-acetyl-D-glucal, alkylation with trimethylaluminum introduced the axial methyl group at C-2 in a stereoselective fashion. Chain extens