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Synthesis of d - and l - myo -Inositol 1,4,6-Trisphosphate, Regioisomers of a Ubiquitous Second Messenger

✍ Scribed by Mills, Stephen J.; Potter, Barry V. L.


Book ID
127095782
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
328 KB
Volume
61
Category
Article
ISSN
0022-3263

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A chemoenzymatic synthesis of d-myo-inos
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Enzyme-catalyzed esterification of racemic 2,3-O-cyclohexylidene-myo-inositol (DL-1) proceeded exclusively in 1,4-dioxane to give optically pure L-1-O-acetyl-2,3-O-cyclohexylidene-myo-inositol (L-2) and D-2,3-O-cyclohexylidene-myo-inositol (D-1). A new practical route has been developed for the synt