Synthesis of Cytotoxic 6 E -Hydroximino-4-ene Steroids: Structure/Activity Studies
✍ Scribed by Deive, Noé; Rodríguez, Jaime; Jiménez, Carlos
- Book ID
- 127038822
- Publisher
- American Chemical Society
- Year
- 2001
- Tongue
- English
- Weight
- 98 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0022-2623
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Two new 6-hydroximino-4-en-3-one steroids: (24R, 6E)-24-ethylcholest-6-hydroximino-4en-3-one (1) and (6E) cholest-6-hydroximino-4-en-3-one (2), accompanied by the known cholest-4-en-3-one wexe isolated from a mixttwe of two morphospecies of the sponge Cinachyrella (C. alloclada and C. apion). Use of
Isolation and Synthesis of the First Natural 6-Hydroximino-4-en-3one Steroids from the Sponges of Cinachyrella spp. -Two new steroids (Ia) and (Ib) are isolated from the title sponges and the structure of (Ia) is confirmed by synthesis from β-sitoesterol. (Ia) does not show any cytotoxic activity a