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Synthesis of cyclopentane analogs of 1-(2′,3′-dideoxy-β- glycero -pentofuranosyl)pyrimidine nucleosides

✍ Scribed by Hronowski, Lucjan J. J.; Szarek, Walter A.


Book ID
124053723
Publisher
NRC Research Press
Year
1988
Tongue
French
Weight
827 KB
Volume
66
Category
Article
ISSN
0008-4042

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## Abstract Free radicals generated by reaction of protected methyl 2,3‐ dideoxy‐3‐iodopentofuranosides 2, 3, and 9 with tributyltin hydride in the presence of a radical initiator (AIBN) were treated with acrolein to give methyl 2,3‐dideoxy‐3‐(3‐oxopropyl)pentofuranosides 4 and 5. Reduction of 5 wi