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Synthesis of Cycloalkanone-Substituted Ketene Aminals and their Reaction with Ethyl Propiolate

โœ Scribed by Huang, Zhi-Tang ;Wang, Xiao-Jun


Publisher
Wiley (John Wiley & Sons)
Year
1987
Tongue
English
Weight
442 KB
Volume
120
Category
Article
ISSN
0009-2940

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Alkylation of Heterocyclic Ketene Aminal
โœ Huang, Zhi-Tang ;Liu, Zhi-Rong ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 445 KB ๐Ÿ‘ 1 views

Heterocyclic ketene aminals 1-3 react with benzyl chloride to give the benzyl-substituted compounds 4-6. With ethyl bromoacetate, 1 -3 react smoothly, and y-iactam-fused heterobicycles 9-11 are obtained by further cyclocondensation of the alkylation products.